2 edition of Biodegradable polymers for the sustained release of antisense nucleic acids. found in the catalog.
Biodegradable polymers for the sustained release of antisense nucleic acids.
Karen Jane Lewis
by Aston University. Department of Biological and Pharmaceutical Sciences in Birmingham
Written in English
Thesis (PhD) - Aston University, 1996.
Since particles that are immobilized by mucus barriers are typically efficiently cleared from the mucosal tissue, the design of biodegradable mucus-penetrating nanoparticle systems capable of sustained drug or nucleic acid delivery has become a priority for the improved treatment of numerous diseases that affect mucosal tissues (2, 36). Using this procedure, molecules for gene therapy (plasmid DNA, antisense oligonucleotide, small interfering RNA) can be adsorbed on the surface or encapsulated into the NPs. An advantage of this method is that the simple evaporation process is performed under mild physicochemical conditions and leads to improved nucleic acid absorption.
Biodegradable and Biobased Polymers for Environmental and Biomedical Applications - Kindle edition by Kalia, Susheel, Avérous, Luc. Download it once and read it on your Kindle device, PC, phones or tablets. Use features like bookmarks, note taking and highlighting while reading Biodegradable and Biobased Polymers for Environmental and Biomedical cturer: Wiley-Scrivener. (e.g. pulmonary delivery). Finally, biodegradable microspheres for nucleic acid delivery allow a full improvement of oligonucleotide pharmacological effect avoiding risks related to the use of viral vectors. 4. Technology key words4. Technology key words Microspheres, biodegradable polymers, proteins, nucleic acids, growth factors 5. 5.
The cellular transport process of DNA is hampered by cell membrane barriers, and hence, a delivery vehicle is essential for realizing the potential benefits of gene therapy to combat a variety of genetic diseases. Virus-based vehicles are effective, although immunogenicity, toxicity and cancer formation are among the major limitations of this approach. Biodegradable polymers are polymers that breakdown within a limited period of time after being placed in the body and are designed to offer temporary support. With an estimated consumption of 68 million kilograms per year in , biodegradable polymers are widely used as biomedical devices and in tissue engineering applications.
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Biodegradable polymer devices may, therefore, be clinically useful for the long- term delivery of antisense nucleic acids. Acknowledgements This work was supported in part by grants from the Cancer Research Campaign, the MRC Aids Directed K.J.
Lewis et al. / Journal of Controlled Release 37 () Programme and the Nuffield by: Release profiles of antisense nucleic acids from films over 28 days was biphasic, characterised by an initial burst release during the first 48 hours followed by a more sustained release.
Release from films of longer antisense nucleic acids was slower compared to shorter nucleic : Karen J. Lewis. Release profiles of antisense nucleic acids from films over 28 days was biphasic, characterised by an initial burst release during the first 48 hours followed by a more sustained release.
Release from films of longer antisense nucleic acids was slower compared to shorter nucleic acids. Inhe became a Full Professor at ECPM (University of Strasbourg), where he teaches polymer science and engineering. During the last two decades, his major research projects have dealt with biobased and/or biodegradable polymers for environmental & biomedical applications.
In this study, we have evaluated the potential use of biodegradable poly-(L-lactic acid) (PLA) polymer matrices to improve the biological stability and provide sustained delivery of a biologically active hammerhead ribozyme designed to cleave the mRNA of the c-myc proto-oncogene.
The in vitro release profile showed that the entrapped hammerhead Cited by: The impact of the injection mold temperature upon polymer crystallization and resulting drug release from immediate and sustained release tablets.
International Journal of Pharmaceutics(), DOI: /m The present invention provides compositions for extended release of a nucleic acid agent, a biodegradable polymer. The present invention also provides methods of producing the matrix compositions and methods for using the matrix compositions to provide controlled release of the nucleic acid.
Alteration of gene expression in animals by introduction of a biodegradable microparticle composition of an antisense oligodeoxyribonucleotide within a biodegradable polymeric matrix into a target cell is provided.
Methods for the controlled delivery of the composition are provided. A well-known issue with biodegradable polymers is uncertainty with regard to the safety of degradation products.
Diffusion of the drug from the solid gel allows for sustained-release formulations. This approach was used in a study describing the release of model protein bovine a critical design consideration for nucleic acid delivery. Sustained release of nanosized complexes of polyethylenimine and anti-TGF-β2 oligonucleotide improves the outcome of glaucoma surgery.
Journal of Controlled Release(3), DOI: /l Discuss; microparticles Substances title claims abstract description 93; antisense oligodeoxyribonucleotide Substances title claims abstract. Biodegradable polymers can be derived from natural resources, such as PLA, or partially made from renewable and synthesized resources, as it happens for bio-based PET .There exist three main categories of biodegradable polymers that were clearly highlighted in Siracusa et al.
: 1. Natural biodegradable polymers: These are derived from natural raw materials and renewable resources. Biodegradable polymers afford protection to nucleic acid drugs and depending on the nature of the formulation it is possible to control the rate of release of the encapsulated drug.
These can be fabricated as implantable devices for local delivery or. However, this is somewhat counterintuitive as compared to the sustained release characteristics of PLGA-based microspheres, for which a long-term sustained release of nucleic acids was found (e.g.
Nucleic acid medicines utilize nucleic acid, such as DNA and RNA (which control genetic information), as drugs. Nucleic acid medicine is a next-generation drug discovery technology with a completely different mechanism of action than traditional pharmaceutical products.
We discuss the different types of nucleic acid medicines in this chapter. nucleic acids to induce the production of proteins (plasmid deoxyribonucleic acid – pDNA, complementary DNA – cDNA, messenger ribonucleic acid – mRNA- and microRNA – miRNA), or to inhibit the transduction of harmful proteins (small inter-fering RNA – siRNA- or antisense oligonucleotides) [13,14].
This volume incorporates 13 contributions from renowned experts from the relevant research fields that are related biodegradable and biobased polymers and their environmental and biomedical applications.
Specifically, the book highlights: Developments in polyhydroxyalkanoates applications in agriculture, biodegradable packaging material and biomedical field like drug delivery systems, implants.
In book: Encyclopedia of Polymer Science and Technology, pp Biodegradable polymers have been used for more than 50 years with diverse applications such as surgical sutures, wound.
The importance of self-assembly between nucleic acids and biodegradable polymers has become increasingly more recognized due to its potential application in biological transport and gene therapy. Biodegradable polymers, as defined in this report, are bio-based or synthetic polymers that undergo microbial decomposition to carbon dioxide and water in industrial or municipal compost facilities.
A few of these polymers decompose in backyard compost bins or in soil, freshwater, or saltwater. Biodegradable polymers are a special class of polymer that breaks down after its intended purpose by bacterial decomposition process to result in natural byproducts such as gases (CO 2, N 2), water, biomass, and inorganic salts.
These polymers are found both naturally and synthetically made, and largely consist of ester, amide, and ether functional groups.The field of gene therapy has experienced an insurgence of attention for its widespread ability to regulate gene expression by targeting genomic DNA, messenger RNA, microRNA, and short-interfering RNA for treating malignant and non-malignant disorders.
Numerous nucleic acid analogs have been developed to target coding or non-coding sequences of the human genome for gene regulation.Nucleic Acid Drugs.
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